Zepbound 2.5mg (Tirzepatide) Starting Dose for Weight Management. Zepbound 2.5mg is the initiation dose of Tirzepatide, a dual GIP and GLP-1 receptor agonist specifically FDA-approved for chronic weight management. This starting strength is designed to introduce the medication to your system, allowing your body to acclimate to the metabolic changes while beginning to regulate hunger and fullness signals. Key Highlights: Initiation Phase: Formulated to minimize side effects during the first 4 weeks. Dual-Targeting: The only weight-loss brand that activates two separate hormone receptors. Appetite Reset: Begins the process of slowing digestion to help reduce caloric intake. Administration: Subcutaneous injection once weekly in the abdomen, thigh, or upper arm. Storage: Store in the refrigerator (2°C to 8°C). Can be kept at room temperature for up to 21 days if needed.